Dr. Maisiah AR
Cranfield MK43 0AL
Diabetic Autonomic Neuropathy (DAN) is associated with a markedly reduced quality of life and poor prognosis. The metabolic hypotheses for diabetic complications include polyol pathway hyperactivity and its related myo-inositol deletion, increased diacylglycerol-protein kinase C cascade, oxidative stress, and non-enzymatic glycation. DAN may affect many organ systems throughout the body as follows: Gastrointestinal [GI], genitourinary, and cardiovascular, Neurovascular system, Respiratory System, Pupillomotor and Neuroendocrine system. The differential diagnosis of DAN includes pure autonomic failure, multiple system atrophy with autonomic failure, Addison’s disease and hypopituitarism, Pheochromocytoma, Hypovolemia. Symptomatic treatment a thorough risk-benefit estimate aimed at maintaining the patient's quality of life is required.