ISSN:2424-9017
Diabetic Autonomic Neuropathy: Biochemical Factors, Diagnosis, Treatment- Literature Review
Article Type: Review Article

Maisiah AR

Cranfield university, Cranfield MK43 0AL, Bedfordshire, UK
Corresponding Author:

Dr. Maisiah AR

Cranfield university                            

Cranfield MK43 0AL

Bedfordshire, UK

Received: 2015-10-28 ; Accepted: 2015-11-16 ; Published: 2015-11-27
Citation: Maisiah AR (2015) Diabetic Autonomic Neuropathy: Biochemical Factors, Diagnosis, Treatment- Literature Review J Diab 1:10440.
Copyright: © 2015 Maisiah AR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Diabetic Autonomic Neuropathy (DAN) is associated with a markedly reduced quality of life and poor prognosis. The metabolic hypotheses for diabetic complications include polyol pathway hyperactivity and its related myo-inositol deletion, increased diacylglycerol-protein kinase C cascade, oxidative stress, and non-enzymatic glycation.  DAN may affect many organ systems throughout the body as follows: Gastrointestinal [GI], genitourinary, and cardiovascular, Neurovascular system, Respiratory System, Pupillomotor and Neuroendocrine system. The differential diagnosis of DAN includes pure autonomic failure, multiple system atrophy with autonomic failure, Addison’s disease and hypopituitarism, Pheochromocytoma, Hypovolemia. Symptomatic treatment a thorough risk-benefit estimate aimed at maintaining the patient's quality of life is required.

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