Dr. Akku S
Diabetes Mellitus is a disease in which a person has high glucose levels in the blood may be due to insufficient production of insulin or body’s cells do not respond to insulin. Diabetes is mainly classified into two types Type I Diabetes and Type II diabetes. Type 1 Diabetes (T1D) is identified by recognition of one or more beta cell proteins by the immune system. Type II Diabetes Mellitus (T2DM) is diabetes which is characterized by hyperglycemia due to lack of insulin. Many advances have been made in recent era of clinical trials in order to understand the human diabetes activation and regulation coupled with lessons towards the development of more effective, multipronged therapies in order to oblate diabetes autoimmunity ,preservation of beta cells ,isolation of immune tolerance and the improvement of lives of patients suffering from T1D.The main objective of this review is to focus on the clinical trials conducted in the past decades for the translation of fundamental findings. Though insulin is known as lifesaving and for sustainment for the patients suffering from T1D, complete curing will be difficult than the simple replacement of the hormone insulin. TID is an autoimmune disease orchestrated by T cells which is related with many immune responses.